The Trua Loop™: an Adaptive Ethics Pipeline

Participant‑led research, ethically adaptive by default

Powered by participant‑derived insight to generate dynamically approved, community‑prioritized research protocols.

The Loop, at a glance

A simple, auditable flow from narrative → computation → adaptive ethics → back to narrative.

Participant NarrativesOpen interviewsComputational SynthesisTopics → Tasks → OutcomesAdaptive Ethics PipelineIRB pre‑clears high‑priority instrumentsResults & findings shared → next round of narratives

Why it matters

Three practical advantages for NHS trusts, NIHR partners, CROs, and sponsors.

  • Scaled PPI: participant voice becomes quantitative evidence, not anecdote.
  • Adaptive by governance: high‑priority outcomes trigger pre‑cleared instruments.
  • Traceable decisions: every survey item links back to originating narratives.

What it is

A participant‑led methodology coupled with an ethics mechanism. Interviews and unstructured data are synthesized with NLP, prioritized by the community, and routed through a standing IRB agreement that pre‑approves instruments in the high‑importance, high‑underserved quadrant.

What you get

  • Topic & task lists with prioritization by cohort
  • Outcome grids (importance × underservedness)
  • Traceable links to the originating qualitative snippets

Where it fits

Pre‑protocol discovery, adaptive protocol updates, and PPI evidence in submissions. Works alongside your existing CRO processes and EDC tools.

Discovery
Open interviews → outcomes
Prioritization
Card sort + Likert scoring
Governance
IRB pre‑clearance window
Iteration
Share back → next loop

Talk to us about the Trua Loop

We can scope a discovery sprint or integrate the Loop within your existing study governance.

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